?Use the lowest effective dose for the patient. The total dose of Ambien should not exceed 10 mg once daily immediately . alone at therapeutic doses, the co-administration of Ambien with alcohol and .. Tolerance may occur to both desired and undesired effects of drugs and may develop at different rates for different. WebMD takes a look at the side effects of popular sleeping pills. Is It Dangerous to Combine Sleeping Pills and Alcohol? Between a third and half of all Americans have insomnia and complain of poor sleep. same receptors in the brain as do benzodiazepines, include Lunesta, Sonata, and Ambien. Discover the dangers of mixing Zolpidem with alcohol and other drugs in this article. Insurance · The Cost of Treatment · What to Bring · Why Travel activity of the brain and nerves can slow down your vital functions to a dangerous rate. Mixing alcohol with Ambien increases both drugs' sedative effects on the central.